Target- Core

Target- Core Ulthrora high performance core-shell cmatographic column

Patented technology of ultra high efficiency core-shell particles

Excellent choice of compounds with similar structure

Excellent peak forms of basic compounds

Withstand 80 ° C high temperature

Wider pH stability tolerance range

Higher back pressure tolerance

characteristic:
The core-shell packing with a particle size of 2.7μm has brought a revolutionary change to HPLC: the separation efficiency is equivalent to that of sub-2μm full bore packing, but the column pressure is only half; therefore, the analyst can use the existing conventional 400-600Bar HPLC instrument, to achieve ultra-high column efficiency and faster separation (see Figure 1). Under the same chromatographic conditions, the target core 2.7um column can exceed most of the sub columns

The column efficiency of 2um full pass chromatographic column, and more importantly, the column pressure is only sub Half or even one third of the 2 um full pass column.

Figure 1. Ultra high column efficiency and faster separation

Understand the performance of core-shell chromatographic column (Figure 2)
The reasons for the ultra-high column efficiency of core-shell chromatographic columns which are widely accepted in chromatographic theory are as follows:

● reduced eddy diffusion: the flow path of the analyte through the column bed is more uniform, resulting in Van Deemter ,The "a term" of the equation is reduced by 40%.

● lower vertical diffusion, flatter van Deemter  Curve and higher  linear velocity: the contribution of solid core of core-shell packing (the "B term" of van Deemter equation is reduced by 30%).

● due to the effective reduction of items a and B, the tray height of core-shell chromatographic column is greatly reduced and the column efficiency is significantly improved.
Figure 2. Van Deemter diagram of the relationship between tray height and linear velocity (velocity)

Influence of particle size and column type
Column type: 4.6 x 50 mm, totally borous C18, 5um;
4.6 x 50 mm, Totally porous C18， 3. 5um;
4.6 x 50 mum,Totally porousC18，1. 8um ;
4.6 x 50 mum,Target-Core C18，2. 7um ;
Mobile phase: 60% acetonitrile / 40% water, 24C
Sample: naphthalene


Some applications
Isomer separation (Figure 3)


Food additives (Figure 4)

Rapid peptide separation (Fig. 5)


Target core C18 and target core PFP separate steroids with similar structure (Figure 6)

Comparison between target core C18 and conventional C18 for separation of Notoginsenoside (Fig. 7)


Stationary phase and related technical parameters

ary phase	Particle size(um)	aperture(Å)	Specificsurface area（㎡)	Carbon load（%）	End base sealing	PHTolerance range	Withstand voltage (psi)	USP
C18	1.8	100	120	7.5	yes	1.5-10.5	15000	L1
C18	2.7	100	130	7.5	yes	1.5-10.5	9000	L1
C18	5	100	120	7	yes	1.5-10.5	7500	L1
C8	2.7	100	130	5	yes	1.5-9.5	9000	L1
PFP	2.7	100	130	5	yes	2-8	9000	L43
Hexyl-Phenyl	2.7	100	130	5	yes	2-8	9000	L11
C30	2.7	100	120	7	yes	1.5-9.5	9000	L62
Hilic-Amide	2.7	100	130	4	no	2-8	9000	L63

    Ordering Information   

 

stationary phase	Specification	Part No
Target-Core C18	2.7um   50×4.6mm	202002-4605
Target-Core C18	2.7um   100×4.6mm	202002-4610
Target-Core C18	2.7um   150×4.6mm	202002-4615
Target-Core C18	2.7um 50×2.1mm	202002-2105
Target-Core C18	2.7um 100×2.1mm	202002-2110
Target-Core C18	2.7um 150×2.1mm	202002-2115
Target-Core C18	5um 150×4.6mm	202012-4615
Target-Core C18	5um 250×4.6mm	202012-4625
Target-Core C8	2.7um 50×4.6mm	202003-4605
Target-Core C8	2.7um 100×4.6mm	202003-4610
Target-Core C8	2.7um 150×4.6mm	202003-4615
Target-Core C8	2.7um 50×2.1mm	202003-2105
Target-Core C8	2.7um 100×2.1mm	202003-2110
Target-Core C8	2.7um 150×2.1mm	202003-2115
Target-Core PFP	2.7um 50×4.6mm	202004-4605
Target-Core PFP	2.7um 100×4.6mm	202004-4610
Target-Core PFP	2.7um 150×4.6mm	202004-4615
Target-Core PFP	2.7um 50×2.1mm	202004-2105
Target-Core PFP	2.7um 100×2.1mm	202004-2110
Target-Core PFP	2.7um 150×2.1mm	202004-2115
Target-Core Hexyl-Phenyl	2.7um 50×4.6mm	202005-4605
Target-Core Hexyl-Phenyl	2.7um 100×4.6mm	202005-4610
Target-Core Hexyl-Phenyl	2.7um 150×4.6mm	202005-4615
Target-Core Hexyl-Phenyl	2.7um 50×2.1mm	202005-2105
Target-Core Hexyl-Phenyl	2.7um 100×2.1mm	202005-2110
Target-Core Hexyl-Phenyl	2.7um 150×2.1mm	202005-2115
Target-Core Hilic-Amide	2.7um 50×4.6mm	202006-4605
Target-Core Hilic-Amide	2.7um 100×4.6mm	202006-4610
Target-Core Hilic-Amide	2.7um 150×4.6mm	202006-4615
Target-Core Hilic-Amide	2.7um 50×2.1mm	202006-2105
Target-Core Hilic-Amide	2.7um 100×2.1mm	202006-2110
Target-Core Hilic-Amide	2.7um 150×2.1mm	202006-2115
Target-Core C30	2.7um 50×4.6mm	202007-4605
Target-Core C30	2.7um 100×4.6mm	202007-4610
Target-Core C30	2.7um 150×4.6mm	202007-4615
Target-Core C30	2.7um 50×2.1mm	202007-2105
Target-Core C30	2.7um 100×2.1mm	202007-2110
Target-Core C30	2.7um 150×2.1mm	202007-2115

* If you need other specifications that are not in this list, please contact your sales representative.